shí yàn shì
实验室
xiǎo shǔ
小鼠
shí dài
时代
de
的
rì luò
日落
：
lèi qì guān
类器官
gǎi biàn
改变
ái zhèng
癌症
yán jiū
研究

The Sunset of the Laboratory Mouse Era: Organoids Changing Cancer Research

本站:Mar 15, 2026原文:Jan 13, 2026

dào到2026nián年，shēng wù yī xué生物医学yán jiū研究kě néng可能huì会chū xiàn出现yí gè一个zhòng yào重要biàn huà变化：kē xué jiā科学家huì会màn màn慢慢jiǎn shǎo减少dòng wù shí yàn动物实验，ái zhèng癌症yán jiū研究yě也kāi shǐ开始shǐ yòng使用yī zhǒng一种xīn新fāng fǎ方法——lèi qì guān类器官。

By 2026, there may be a significant change in biomedical research: scientists will gradually reduce animal experiments, and cancer research will begin to use a new method—organoids.

lèi qì guān类器官shì是yòng用rén tǐ人体gàn xì bāo干细胞huò或bìng rén病人de的zhǒng liú肿瘤zǔ zhī组织péi yǎng培养chū lái出来de的sān wéi三维“xiǎo zhǒng liú小肿瘤”。

Organoids are three-dimensional 'mini tumors' grown from human stem cells or a patient's tumor tissue.

guò qù过去，kē xué jiā科学家cháng yòng常用píng miàn平面de的xì bāo péi yǎng细胞培养hé和xiǎo shǔ小鼠zuò做shí yàn实验，dàn但zhè xiē这些fāng fǎ方法hé和rén tǐ人体zhēn shí真实qíng kuàng情况hái shì还是yǒu有chā bié差别，suǒ yǐ所以yǒu xiē有些zài在shí yàn shì实验室lǐ里yǒu xiào有效de的yào药，dào到le了bìng rén病人shēn shàng身上què却méi yǒu没有hǎo好jié guǒ结果。

In the past, scientists often used flat cell cultures and mice for experiments, but these methods differ from the real human situation, so some drugs effective in the lab did not work well in patients.

lèi qì guān类器官bǎo liú保留le了hěn很duō多bìng rén病人zhǒng liú肿瘤de的tè diǎn特点，kē xué jiā科学家kě yǐ可以xiān先zài在zhè xiē这些“xiǎo zhǒng liú小肿瘤”shàng上cè shì测试yào wù药物，kàn kàn看看nǎ zhǒng哪种yào药gèng更kě néng可能yǒu xiào有效，nǎ zhǒng哪种yào药kě néng可能méi yòng没用。

Organoids retain many characteristics of a patient's tumor, allowing scientists to test drugs on these 'mini tumors' first to see which drugs are more likely to be effective and which may not work.

zhè yàng这样，yī shēng医生yǐ hòu以后yě xǔ也许néng能wèi为bù tóng不同bìng rén病人xuǎn zé选择gèng更hé shì合适de的zhì liáo治疗fāng fǎ方法。

This way, doctors may be able to choose more suitable treatments for different patients in the future.

xiàn zài现在，lèi qì guān类器官yǐ jīng已经bèi被yòng yú用于jié zhí cháng ái结直肠癌、rǔ xiàn ái乳腺癌、fèi ái肺癌、qián liè xiàn ái前列腺癌hé和luǎn cháo ái卵巢癌děng等yán jiū研究。

Currently, organoids are already used in research on colorectal cancer, breast cancer, lung cancer, prostate cancer, and ovarian cancer.

tā它yě也néng能jiǎn shǎo减少yī bù fèn一部分dòng wù动物shí yàn实验。

They can also reduce some animal experiments.

bù guò不过，lèi qì guān类器官hái还bù不wán měi完美，bǐ rú比如tā它tōng cháng通常méi yǒu没有xuè guǎn血管hé和miǎn yì免疫xì bāo细胞。

However, organoids are not perfect; for example, they usually lack blood vessels and immune cells.

suī rán虽然rú cǐ如此，zhè这xiàng项jì shù技术fā zhǎn发展hěn很kuài快，wèi lái未来kě néng可能zài在ái zhèng癌症zhì liáo治疗zhōng中fā huī发挥gèng更dà大zuò yòng作用。

Nevertheless, this technology is developing rapidly and may play a greater role in cancer treatment in the future.

Source:Sunset of the lab mouse era

By Neha Dutta Shiv Nadar University, Delhi-NCR / 360info|CC BY 4.0|Modified & AI-assisted

shí yàn shì实验室xiǎo shǔ小鼠shí dài时代de的rì luò日落 ：lèi qì guān类器官gǎi biàn改变ái zhèng癌症yán jiū研究

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shí yàn shì
实验室
xiǎo shǔ
小鼠
shí dài
时代
de
的
rì luò
日落
：
lèi qì guān
类器官
gǎi biàn
改变
ái zhèng
癌症
yán jiū
研究